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Sleep deprivation can be dangerous, but it’s difficult to measure.Credit: GettyHow does the brain know when it’s time to wake up? Researchers have identified1 a chemical signal that serves as a timer in the mouse brain, logging both the length of a single sleep session and the number of interruptions and predicting exactly how likely an animal is to wake up at any given moment.The sleep paradox: why do humans sleep so little when we need it so much?This signal could offer a new way to measure ‘sleep debt’, or accumulated sleep loss. Such a biomarker could one day lead…

Paolo Maldini and Leonardo have reportedly resigned from their roles with the Italian football federation in the wake of Andrea Pirlo’s appointment as Italy head coach falling through.skip past newsletter promotionFree newsletter | Every weekdaySign up to Football DailyKick off your evenings with the Guardian’s take on the world of footballafter newsletter promotionBoth figures had recently taken on roles as part of an overhaul of the national team management. Maldini ‌was appointed ‌on 11 ‌July as technical director of the Italian federation, to help to rebuild the national side after they failed to qualify for a third successive World Cup…

D4vd‘s murder case will go to trial, a Los Angeles judge ruled Monday, per Rolling Stone, with the singer facing charges of killing and sexually abusing 14-year-old Celeste Rivas Hernandez. Prosecutors laid out evidence for the case during the hearing since last week, showing gruesome photos of Hernandez’s body, as well as text messages between her and D4vd, whose real name is David Burke. “It appears to me, for the purposes of preliminary hearing, the people have met their burden of proof on all charges,” Judge Charlaine Olmedo said in court monday, per Rolling Stone, which reported that his arraignment…

When you hear the words capsule wardrobe, you probably picture beige knits and minimalist tailoring. A capsule isn’t just about dressing neutrally, though: it’s about choosing a handful of pieces that work together in countless combinations.The Guardian’s journalism is independent. We will earn a commission if you buy something through an affiliate link. Learn more.There is no time that skill is more important than when you’re packing for a holiday. I have streamlined my approach by sticking to a simple rule of thumb: instead of packing for every possible scenario, I focus on versatile staples that can be dressed up or…

PM salutes ‘giants of the labour movement’Dan Jervis-BardyIn a statement, the prime minister, Anthony Albanese, described Sally McManus and Michele O’Neil as personal friends and “giants of the labour movement”.He said: double quotation markWorking families are in a stronger financial position today than they would otherwise be because of the tireless advocacy and strong leadership of Sally McManus and Michele O’Neil. Sally and Michele secured incredible successes for working people in their eight years together leading Australia’s union movement – the first all-female leadership team in the Australian Council of Trade Unions’ 99-year history. It is fitting that Sally and…

Burke’s arraignment is scheduled for 31 August. The trial is to start within 90 days of that date.Prosecutors have alleged Burke stabbed the teen before dismembering her body after years of alleged sexual abuse.They allege he killed her because the teen had threatened to reveal his relationship with a minor and destroy his multi-million dollar music career.Evidence read in court on Monday showed threats Celeste made to Burke on 22 April 2025, stemming from arguments about his friendship with another girl.”I swear to GOD I will kill u”, one expletive-laden text said, followed by a threat to strangle him and…

FCMB Group deployed a mix of strategies, including top-line expansion and cost management, to deliver a 90.5 per cent increase in net profit for the six months to June, compared with a year earlier, the latest accounts of the bank holding company published on Monday showed. Gross earnings climbed to N676.2 billion from N529.2 billion, with 88.8 per cent of it solely contributed by interest and discount income, setting the scene for the big earnings boost, which was partly driven by a reduction in some major expenses. Cost-to-income ratio dropped to 41.4 per cent from 57 per cent one year…

Last year, the FDA also announced that it was delaying a new rule on food traceability, which would have made it easier for FDA investigators to identify and remove from the market foods linked to illnesses, such as Taylor Farms’ lettuce. “Catastrophic” mismanagement Last week, Kennedy claimed that the Cyclospora surge was “under control,” but critics and former FDA officials have scoffed at the statement. “If history is any judge, when the Trump administration declares a crisis ‘under control’, it’s time to brace for the worst yet to come,” Brad Woodhouse, president of the public health nonprofit Protect Our Care,…

Police are “conducting inquiries” into an image shared by Green party leader Zack Polanski on Instagram after Reform UK reported it for “inciting murder”.The image showed a man wearing a black T-shirt with the words “we’re only making plans for Nigel”, alongside a photograph of a guillotine.A Green party spokesperson said that Polanski “condemns the image on the T-shirt” and accepted being tagged in a post with 20 images “without realising there was more to it than he had seen”.Nigel Farage shared a screenshot of the image on X and wrote: “This is what Zack Polanski has just posted on…

Force of Nature: Understanding Evolution’s Deepest Logic — and Putting It to Use Owen D. Jones W. W. Norton (2026)From antimicrobial resistance and vaccines to drugs design and even policymaking, evolution is fundamental to many aspects of our lives. Yet, too often, Darwinian thinking is neglected.In Force of Nature, biologist and legal scholar Owen Jones argues convincingly that understanding how evolution by natural selection works can inform humans’ interactions with their environment and with each other — and that misunderstanding it can create problems. He cites case studies from a range of fields, including medicine, agriculture and law, to support…