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Heme biosynthesis is tightly coordinated to support essential functions without accumulating toxic porphyrins and depleting cellular iron. Heme induces degradation of the heme biosynthetic enzyme, 5-aminolevulinate synthase (ALAS), by the mitochondrial …

The 2026 trade deadline is set for Monday, Aug. 3, and the deals look like they could go right down to the last minute Aug 1, 2026 at 2:26 pm ET • 1 min read The muddled standings in almost every division and both wild-card races have turned the 2026 MLB trade deadline into a seller’s paradise. Will the Tigers move Tarik Skubal? Do the Red Sox go all in after their 15-game winning streak turned them into buyers? Just how deep will the Mets tear it down?The deadline is set for 6 p.m. on Monday, Aug. 3, and it…

If you purchase an independently reviewed product or service through a link on our website, Variety may receive an affiliate commission. After a thrilling and dazzling Night of Champions, WWE travels to Minnesota for an epic WWE SummerSlam — a premium live event starting on Saturday, Aug. 1. The two-night event features six title bouts, including matches for the Women’s World Championship, World Heavyweight Championship, WWE Intercontinental Championship and others. In 2025, WWE drew in upwards of 1.7 million viewers for SummerSlam. The company hopes that this year’s major would bring in even more viewers. In addition, it’s likely there…

The full details of the decision of the Legal Practitioners Disciplinary Committee (LPDC) suspending Joe-Kyari Gadzama, a Senior Advocate of Nigeria (SAN), from legal practice for three years have emerged. The committee suspended Mr Gadzama after finding him guilty of professional misconduct in the long-running dispute over compensation for victims of the 2001 Zaki-Biam military operation in Benue State. It also suspended another lawyer, Ocha Ulegede, for two years over professional misconduct arising from the same dispute. But the findings against Mr Gadzama were more severe than previously reported by PREMIUM TIMES and other news outlets. In its 70-page direction…

Despite decades of scientific advances, malaria remains one of the world’s deadliest yet most preventable diseases, particularly across Africa. Caused by Plasmodium parasites transmitted through the bites of infected female Anopheles mosquitoes, the disease continues to pose a major public health challenge despite sustained global intervention. The female Anopheles mosquito, which bites mainly between dusk and dawn, is the primary carrier of the parasite. While malaria cannot be transmitted through casual contact such as hugging, coughing or sharing food, it can be passed from a pregnant mother to her unborn child during pregnancy or childbirth. For many people, mosquito bites…

In its latest heatwave bulletin published on Saturday, the Italian health ministry says that by Monday, some 25 of the country’s 27 major cities will be on red alert.It says it expects only two – Reggio Calabria in the southern tip of Italy’s “boot” and Messina, facing it across on the island of Sicily – to be on the second-highest “amber” alert.The ministry urges residents in the affected areas to avoid exposure to heat and direct sunlight during the hottest hours between 11:00 and 18:00, stay indoors and drink plenty of fluids.The extreme heat is being caused by a subtropical…

Investment company VFD Group recorded a twofold increase in net profit for the first half of the year, supported by a significant improvement in investment income, its unaudited report for the period issued Friday showed. VFD Group is proprietary and investment-focused, meaning it invests in target companies for direct market gain, unlike investment banks, which invest on behalf of others. It has investments in companies as diverse as the Nigerian Exchange Group, Veritas Kapital Assurance, NASD Plc and CSCS Plc, according to information on its website. Revenue advanced to N53.7 billion from N41.2 billion a year ago, deriving strength largely…

Christopher Nolan’s The Odyssey has been a lightning rod for controversy ever since the first casting and design reveals, igniting afresh with each new trailer. The film has garnered plenty of well-deserved accolades (and earnings) since its release, and yet somehow the debates rage on between classicists and the general public alike—all this over an adaptation of an epic poem that’s been around since roughly the 8th century BCE. My take: the IMAX scale might be epic, but Nolan gives the story an intimate feel, weaving a captivating, nearly three-hour cinematic spell. While the magic slowly starts to dissipate once…

This time last year, Nigel Farage was making the political weather. His freewheeling weekly press conferences filled a sparse news agenda, setting out eye-catching policies on areas such as crime and immigration. This year? Less so.The Reform UK leader is expected to hold a press conference in London next week. If so, it would be just his third since May’s local elections and the first in the capital in more than three months. The man who was everywhere now appears to be in hiding.There is an obvious context. The UK has a new prime minister and Farage’s aides are clear…

The Ebola outbreak caused by the Bundibugyo virus in the Democratic Republic of the Congo (DRC) has intensified, with 3,605 confirmed cases and 1,587 deaths recorded as of 30 July. In a situation update released on Saturday, the World Health Organisation (WHO) warned that sustained transmission and the disease’s expanding geographical spread continue to fuel what has become the country’s largest Ebola outbreak on record. The agency said the rapid rise in infections and deaths highlights the urgent need to scale up response efforts. Outbreak reaches five provinces WHO said the outbreak was initially confined to the Mongbwalu Health Zone…